Structurally, no, TJI® joists are manufactured without camber and with uniform properties regardless of orientation. However, the location of the pre-punched knockout holes will tend to be nearer one flange, so a builder might choose to install them with the holes down, to ease wiring or plumbing installations. Installing TJI® joists in a roof, with the holes near the top, might allow a builder to gain some cross ventilation from joist bay to joist bay.
One additional reason to pay attention to orientation of the joists is the use of TJI® Flak Jacket™ fire protection. In this case, the fire resistance of the product is dependent upon proper installation of the joist ("Up" direction is shown on the web of the joist).